Department of Chemical Biology, CCME, PKU
Synthetic and Functional Biomolecules Center, PKU
Peking-Tsinghua Joint Center for Life Science
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Research interests:
Development and application of bioorthogonal chemical reactions on living systems, to provide innovative tools for life science research and develop innovative technologies for diagnostics and therapeutics through the chemical knowledge and tools.
1.Bioorthogonal chemistry: development and application of bioorthogonal chemistry and chemical tools for life sciences.
2.Protein engineering and omics: protein engineering and multi-omics technology.
3.Immune chemical biology: interactions between biomacromolecules as well as cells in the regulations and interventions of immune systems.
(See research page for more details!)
Selected References:
1, Liu J, Yan X, Wu H, Ji Z, Shan Y, Wang X, Ran U, Ma Y, Li C, Zhu Y, Gu R, Han W, Yi C*, Chen P*, “RNA codon expansion via programmable pseudouridine editing and decoding”, Nature, (2025), 643, 1410-20.
2, Wang X, Liu Y, Wang Z, Zeng X, Ngai WSC, Wang J, Zhang H, Xie X, Zhu R, Fan X, Wang C*, Chen P*, “Machine-learning-assisted universal protein activation in living mice”, Cell, (2025),188, 3696-3714.
3, Li K, Xie X, Gao R, Chen Z, Yang M, Wen Z, Weng Y, Fan X, Zhang G, Liu L, Zeng X, Han Y, Cao M, Wang X, Li J, Yang Z, Li T, Chen P*, “Spatial-temporal protein interactome profiling through condensation enhanced photo-crosslinking”, Nat. Chem., (2025), 17, 111-23.
4, Lin F, Yin S, Zhang Z, Yu Y, Fang H, Liang Z, Zhu R, Zhou H, Li J, Cao K, Guo W, Qin S, Zhang Y, Lu C, Li H, Liu S, Zhang H, Ye B, Lin J*, Li Y*, Kang X*, Xi J*, Chen P*, “Multimodal targeting chimeras enable integrated immunotherapy leveraging tumor-immune microenvironment”, Cell, (2024), 187, 7470-91.
5, Zhu Y, Ding W, Fan X*, Lin S*, Chen P*, “Genetically encoded bioorthogonal tryptophan decaging in living cells”, Nat. Chem., (2024), 16, 533-42.
6, Weng Y, Chen W, Kong Q, Wang R, Zeng R, He A, Liu Y, Mao Y, Qin Y, Ngai WSC, Zhang H, Wang J, Ke M, Tian R*, Chen P*. “DeKinomics pulse-chases kinase functions in living cells”, Nat. Chem. Biol. (2024), 20, 615-23.
7, Qin F*, Li B, Wang H, Ma S, Li J, Liu S, Kong L, Zheng H, Zhu R, Han Y, Yang M, Li K, Ji X*, Chen P*. “Linking chromatin acylation mark-defined proteome and genome in living cells”, Cell, (2023), 186, 1066-85.
8, Wang J, Liu Y, Liu YJ, Zheng S, Wang X, Zhao J, Yang F, Zhang G, Wang C*, Chen P*. “Time-resolved protein activation by proximal decaging in living systems”. Nature, (2019), 569, 509-13.
9, Li J, Jia S, Chen P*. “Diels-Alder reaction-triggered bioorthogonal protein activation in living cells”, Nat. Chem. Biol., (2014), 10, 1003-5.
10, Li J, Yu J, Zhao J , Wang J, Zheng S, Lin S, Chen L, Yang M, Jia S, Zhang X, Chen P*. “Palladium-triggered deprotection chemistry for protein activation in living cells”, Nat. Chem. (2014), 6, 352-61.